Indication & Dosage LACTAZON S
Meningitis, Respiratory tract infections, Skin and soft tissue infections, Intra-abdominal infections, Urinary tract infections, Septicaemia, Bone and joint infections, Gynaecological infections Adult: Ratio of sulbactam:cefoperazone is 1:1. Doses are expressed in terms of cefoperazone. Mild to moderate infections: 1-2 g daily, given in equally divided doses every 12 hr. Severe infections: Up to 4 g daily, given in equally divided doses every 12 hr; max dose of sulbactam: 4 g daily. Child: Ratio of sulbactam:cefoperaone is 1:1. Doses are expressed in terms of cefoperazone. Recommended doses: 20-40 mg/kg/day, given in equally divided doses every 6-12 hr. For serious infections: Up to 160 mg/kg/day, given in 2-4 equally divided doses may be used. Max dose of sulbactam: 80 mg/kg/day Renal impairment: Dose adjustments may be needed.
Hypersensitivity. Known allergy to penicillins.
Adverse Drug Reactions
Rash, skin reactions, fever, eosinophilia, urticaria, and pruritus. Haematological - Slight decreases in Hb conc and haematocrit value. GI effects, diarrhoea or loose stools, nausea, and vomiting. Mild, transient elevations of serum SGOT, SGPT, and alkaline phosphatase concentrations. Renal effects - Transient elevations in BUN and serum creatinine concentrations.
With aminoglycosides: Concomitant admin may increase risk of nephrotoxicity. With heparin/warfarin: Concurrent use may cause marked hypoprothrombinemia and/or prolonged bleeding time.
Intravenous: Before reconstitution: Store below 25°C. Reconstituted solutions are stable for 7 days at 2-8°C and for 24 hr at 8-25°C. All unused portions after the above stated time periods should be discarded.
Mechanism of Action
Cefoperazone, a bactericidal antibiotic, inhibits bacterial cell wall synthesis of actively dividing cells by binding to one or more penicillin binding proteins (PBPs). Sulbactam is a β-lactamase inhibitor and acts primarily by irreversible inactivation of β-lactamases.
J01CG01 - sulbactamBelongs to the class of beta-lactamase inhibitors. Used in the systemic treatment of infections. J01DD12 - cefoperazoneBelongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.